The Metabolism of L - Fucose
نویسنده
چکیده
The isomerization of L-fucose to L-fuculose was observed by Green and Cohen (2) in extracts obtained from Escherichia coli grown on L-fucose. With the same organism and similar conditions, Huang and Miller (3) suggested that such extracts catalyzed the phosphorylation of both L-fucose and L-fuculose to form the corresponding sugar l-phosphates. The present report describes the partial purification and the properties of an enzyme from Escherichiu coli O-111 Bd or Escherichia freundii which, in the presence of adenosine triphosphate and Mg++, catalyzes the phosphorylation of L-fuculose but not of L-fucose. The product of the reaction was isolated and characterized as L-fuculose l-phosphate by periodate oxidation studies.
منابع مشابه
بررسی سطح ادراری قند ال-فوکوز در بیماران مبتلا به سرطان های دستگاه گوارش و ژنیکولوژیک
L-fucose (6.deoxy. L.galactose) is the only monosacharide which is placed in non reducting position of glycoproteins structure in L-deoxy form. L-fucosidase and fucosy 1 transferase directly take part in the elevation or decrease of sorum L-fucose levels. Tumors may directly induce enzymes that release L-fucose from glycoproteins formed in the neoplastic tissue, or the glycoproteins may be rele...
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تاریخ انتشار 2003